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Hiroaki Shimokawa Selected Research

Arteriosclerosis

1/2016RhoA/Rho-Kinase in the Cardiovascular System.
5/2015Light and Dark of Reactive Oxygen Species for Vascular Function: 2014 ASVB (Asian Society of Vascular Biology).
1/2015Significance of nitric oxide synthases: Lessons from triple nitric oxide synthases null mice.
1/2013Rho-kinase inhibitors.
8/2011Rho-kinase: important new therapeutic target in cardiovascular diseases.
4/2007Recent progress in the treatment of pulmonary arterial hypertension: expectation for rho-kinase inhibitors.
3/2007Progress of the study of rho-kinase and future perspective of the inhibitor.
12/2006Long-term inhibition of Rho-kinase ameliorates hypoxia-induced pulmonary hypertension in mice.
9/2005Rho-kinase is an important therapeutic target in cardiovascular medicine.
1/2005Therapeutic potential of rho-kinase inhibitors in cardiovascular diseases.
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Hiroaki Shimokawa Research Topics

Disease

68Heart Failure
06/2022 - 03/2002
47Cardiovascular Diseases (Cardiovascular Disease)
01/2022 - 03/2002
44Myocardial Infarction
01/2022 - 05/2004
41Pulmonary Hypertension
01/2021 - 07/2002
39Myocardial Ischemia (Ischemic Heart Diseases)
01/2021 - 01/2002
29Inflammation (Inflammations)
02/2022 - 02/2002
28Spasm (Spasms)
02/2022 - 02/2002
28Hypertension (High Blood Pressure)
01/2022 - 04/2002
27Coronary Artery Disease (Coronary Atherosclerosis)
10/2022 - 01/2002
25Stroke (Strokes)
01/2022 - 02/2002
24Hypoxia (Hypoxemia)
01/2021 - 07/2002
22Ischemia
09/2021 - 07/2003
21Pulmonary Arterial Hypertension
01/2021 - 01/2005
20Coronary Vasospasm (Coronary Artery Vasospasm)
02/2022 - 03/2002
20Fibrosis (Cirrhosis)
01/2021 - 02/2002
19Shock
01/2022 - 11/2004
17Arteriosclerosis
01/2016 - 02/2002
15Thrombosis (Thrombus)
01/2022 - 04/2002
15Atherosclerosis
10/2018 - 03/2002
13Atrial Fibrillation
01/2022 - 12/2016
11Reperfusion Injury
01/2016 - 08/2004
10Hypertrophy
01/2021 - 10/2003
10Cardiomyopathies (Cardiomyopathy)
01/2021 - 05/2002
9Hemorrhage
01/2022 - 02/2008
8Pathologic Constriction (Stenosis)
01/2022 - 04/2002
8Neoplasms (Cancer)
01/2022 - 11/2010
8Ventricular Tachycardia
12/2021 - 01/2015
8Chest Pain (Chest Pains)
01/2021 - 03/2002
8Angina Pectoris
06/2020 - 01/2005
8Diabetes Mellitus
01/2020 - 10/2004
7Unstable Angina
01/2022 - 01/2016
7Vascular Remodeling
01/2018 - 12/2002
7Ventricular Remodeling
01/2018 - 05/2004
7Vascular Diseases (Vascular Disease)
11/2010 - 02/2002
6Death (Near-Death Experience)
01/2022 - 09/2010
6Cardiac Sudden Death (Sudden Cardiac Arrest)
12/2021 - 05/2004
6Cardiomegaly (Heart Hypertrophy)
05/2016 - 01/2005
5Acute Coronary Syndrome
11/2021 - 04/2002
5Ischemic Stroke
09/2021 - 12/2016
5Embolism (Embolus)
09/2021 - 12/2016
5Cognitive Dysfunction
01/2021 - 01/2017
5Atherosclerotic Plaque (Atheroma)
12/2020 - 04/2002
5Infarction (Infarctions)
01/2018 - 07/2004
5Right Ventricular Hypertrophy
06/2014 - 02/2004
4Ventricular Fibrillation
12/2021 - 04/2009
4Stable Angina
11/2021 - 01/2005
4Coronary Stenosis (Coronary Artery Stenosis)
01/2021 - 03/2003
4Left Ventricular Dysfunction
08/2020 - 05/2004
4Tachycardia (Tachyarrhythmias)
06/2020 - 05/2007

Drug/Important Bio-Agent (IBA)

78rho-Associated KinasesIBA
12/2019 - 02/2002
29fasudil (AT 877)IBA
12/2019 - 04/2002
24Nitric Oxide (Nitrogen Monoxide)FDA Link
01/2019 - 02/2002
17Acetylcholine (Acetylcholine Chloride)FDA Link
02/2022 - 03/2002
16Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
10/2022 - 07/2003
16Vasodilator Agents (Vasodilators)IBA
02/2021 - 07/2003
16Proteins (Proteins, Gene)FDA Link
01/2021 - 07/2002
13Biomarkers (Surrogate Marker)IBA
12/2020 - 05/2008
12Nitric Oxide Synthase (NO Synthase)IBA
11/2021 - 02/2004
11omega-Chloroacetophenone (Mace)IBA
11/2021 - 09/2010
11Brain Natriuretic Peptide (Natrecor)FDA Link
01/2019 - 09/2008
11Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA
09/2018 - 02/2002
10Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
05/2019 - 07/2003
10hydroxyfasudilIBA
02/2016 - 02/2002
10Angiotensin IIIBA
05/2015 - 02/2002
10Monomeric GTP-Binding ProteinsIBA
01/2015 - 02/2002
9Protein Isoforms (Isoforms)IBA
11/2021 - 07/2005
9MonocrotalineIBA
01/2021 - 02/2004
9CytokinesIBA
01/2021 - 05/2002
9NitratesIBA
08/2020 - 10/2004
9Reactive Oxygen Species (Oxygen Radicals)IBA
08/2020 - 02/2003
8Cyclophilin AIBA
01/2021 - 11/2010
7LipidsIBA
10/2022 - 09/2010
7Lactic Acid (Lactate)FDA LinkGeneric
01/2021 - 03/2002
6LDL CholesterolIBA
10/2022 - 09/2010
6Calcium Channel Blockers (Blockers, Calcium Channel)IBA
02/2022 - 10/2004
6RivaroxabanIBA
09/2021 - 12/2016
6CreatinineIBA
01/2021 - 09/2004
6ErythropoietinFDA Link
10/2011 - 03/2006
5Angiotensin Receptor AntagonistsIBA
01/2022 - 07/2013
5Pharmaceutical PreparationsIBA
12/2020 - 07/2013
5Messenger RNA (mRNA)IBA
12/2020 - 07/2002
5Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
08/2020 - 09/2006
5Serotonin (5 Hydroxytryptamine)IBA
02/2017 - 02/2002
5endothelium-dependent hyperpolarization factor (EDHF)IBA
01/2015 - 05/2005
4pitavastatin (itavastatin)FDA Link
10/2022 - 01/2018
4AnticoagulantsIBA
01/2022 - 11/2008
4Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA
01/2022 - 03/2009
4LDL Receptors (LDL Receptor)IBA
01/2021 - 09/2010
4Hemoglobins (Hemoglobin)IBA
01/2020 - 08/2008
4Glucose (Dextrose)FDA LinkGeneric
12/2019 - 03/2011

Therapy/Procedure

67Therapeutics
10/2022 - 09/2002
18Extracorporeal Shockwave Therapy
12/2020 - 11/2004
14Percutaneous Coronary Intervention
01/2021 - 01/2005
10Stents
03/2020 - 04/2002
9Implantable Defibrillators (Implantable Cardioverter-Defibrillator)
02/2022 - 04/2009
6Catheter Ablation
06/2021 - 01/2015
6Ligation
01/2019 - 12/2002
5Drug-Eluting Stents
01/2021 - 01/2012
5Coronary Artery Bypass (Coronary Artery Bypass Surgery)
10/2011 - 09/2004
4Secondary Prevention
02/2022 - 02/2012